Figure 4.

The effect of α-asarone on the activation status of NF-κB, degradation of IκB-α, p-IκB-α, and reduction of IKK-β and p-IKK-β after SE induction. EMSA analysis for NF-κB nuclear translocation (A), western blot for IκB-α (B) and IKK-β (C). The quantitative data are presented on each panel, respectively. Protein expression of GAPDH was used as the internal control for Western bloat protein loading. Con, control group; SE, status epilepticus model group; SE-asarone, pretreatment with α-asarone group before SE induction; NF-κB, nuclear factor-κB; EMSA, electrophoresis mobility shift assay; IκB-α, inhibitor kappa B-alpha; IKK-β, I kappaB kinase-β. x ± s, n = 5. *p < 0.05, **p < 0.01, vs. Con group; ^#p < 0.05, ^##p < 0.01, vs. SE group.