Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 18;8:2164. doi: 10.1038/s41467-017-02355-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — ANGPTL8 and p62 collaboratively mediate the autophagic degradation of IKKγ. a The effects of ubiquitin on the ANGPTL8-mediated IKKγ degradation in HEK293T cells. Ubi-WT, the wild-type ubiquitin; Ubi-K63, the ubiquitin in which all of lysine (K) mutated to arginine (R) except K63. b The effect of deubiquitinase CYLD on the ANGPTL8-mediated IKKγ degradation. c The effects of different autophagic adaptors on the ANGPTL8-mediated IKKγ degradation. d Overexpression of p62 but not Tollip-mediated IKKγ degradation is attenuated in ANGPTL8 ^−/− cells. e ANGPTL8 interacts with p62 but not Tollip in the mammalian overexpression system. f ANGPTL8-mediated IKKγ degradation is decreased in p62-RNAi stable cell line. Data are representative of three independent experiments