Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Dec 18;7:17689. doi: 10.1038/s41598-017-16627-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Algorithm to connect level-3 SCPs beyond family relationships defined by the initial taxonomy. One level-3 SCP at a time was removed from the ontology and the remaining level-3 SCPs were re-populated. Each of the remaining SCPs was analyzed, if it contained genes of the removed SCP, either as a new member or as a member that showed increase in rank. Changes were quantified and results associated with SCP pairs. The newly identified SCP interactions are shown by dashed lines while the original taxonomy is shown as solid arrows. All predicted interaction partners of three SCPs Urea cycle, Citric acid cycle, and Electron transport chain are shown. To illustrate the hierarchical relationships all level-2 parent SCPs (light red) and level-1 grandparent SCPs (dark red) are also shown.