Fig. 7.

Fast backbone dynamics are present at distal sites of pSrcKD•dasatinib. a The H-X NOE ratio which indicates motions on the pico- to nanosecond timescale are mapped to the structure of SrcKD•dasatinib (PDB: 3G5D). b S ² order parameters predicted from NMR chemical shifts report on the amplitude of displacement of the backbone amide bond vector from its mean position on the pico- to nanosecond dynamics timescale (fast internal motions). The H-X NOE ratio and S ² values are indicative of flexible and rigid backbone regions. Both show similar regions of flexibility and rigidity. The thickness of the backbone and the corresponding color shown in the key reflects the extent of flexibility/rigidity. Here dasatinib is omitted from the structure for clarity