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. 2017 Dec 18;7:17748. doi: 10.1038/s41598-017-17669-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histology in spleen and liver tissue of T cell treated SCID mice. (a) Low magnification (×5) fluorescent image of the spleen tissue displays prominent CD3 + CAR T cell infiltrates (green). (b) Untransduced T cells also localize to the spleen (scale bars = 50 μm). (c). Confocal images (×63) show that dual-mode PFC nanoemulsion (red) does not colocalize within phagocytic cells (F4/80 staining, green) in the tumor (c) and spleen (d) at day 2 after infusion. (e) Conversely, F4/80 staining in the liver tissue displays dual-mode PFC (red) colocalizing with Kupffer cells or liver macrophages (scale bars = 25 μm).