Table 3.
Studies comparing standard and hypofractionated radiotherapy in elderly patients with GBM
| Author Year | Age | N | OS (month) Std-RT | OS (month) Hypo-RT | Hazard ratio (95% CI) | P |
|---|---|---|---|---|---|---|
| Roa 200435) | ≥60 years | 100 | 5.1 | 5.6 | 0.89 (0.59–1.36) | 0.57 |
| Malmström 201223) | 60–70 years | 198 | 7.6 | 8.8 | 1.06 (0.73–1.54) | 0.77 |
| >70 years | 81 | 5.2 | 7.0 | 0.59 (0.37–0.93) | 0.02 | |
| Minniti 201538) | ≥65 years | 329 | 12.0 | 12.5 | 0.500 | |
| propensity matched analysis | 90 | 0.93 (0.66–1.31) | 0.70 | |||
| Guedes de Castro* 201737) | ≥65 years | 61 | 6.2 | 6.8 | NA | 0.936 |
| ≥65 years, KPS 50–70 | 40 | 6.7 | 7.5 | 0.904 | ||
| ≥65 years, KPS >80 | 21 | 8.0 | 8.0 | 0.890 |
Hypo-RT: hypofractionated radiotherapy, KPS: Karnofsky performance status, OS: overall survival, Std-RT: standard radiotherapy.
*
Lower-dose radiotherapy: 40 Gy/15 fr for Std-RT and 25 Gy/5 fr for Hypo-RT.