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Anticoagulant activity in plasma samples taken from rats with single bolus injection of aptamer RA-36 (A,C,E; 7, 21, and 42 mg/kg doses; 10 animals per dose), as well as bivalirudin (B,D,F; 0.19, 0.38, and 0.75 mg/kg doses; 10 animals per dose). (A,B) TT test; (C,D) PT test; (E,F) APTT test. Data points with clotting time ≥ 200 s are marked with arrows; the points corresponds non-clotting during the measurement limit of coagulometer.
