Table 2.
Pharmacokinetic parameters of two compartment model of elimination of aptamer RA-36 from blood.
| Parameter | A, μg/ml | B, μg/ml | α, min-1 | β, min-1 | Tα, min | Tβ, min | ||
|---|---|---|---|---|---|---|---|---|
| Mean value (lower and upper 95% CI of mean) | 59 (37–81) | 6.9 (5.5–8.2) | 0.70 (0.50–0.90) | 0.030 (0.022–0.038) | 1.0 (0.8–1.4) | 23 (18–32) | ||
| Parameter | k12, min-1 | k21, min-1 | kel, min-1 | V1, ml | V2, ml | Vss, ml | AUC0-∞, μg⋅min/ml | Cl, ml/min |
| Estimated value | 0.42 | 0.10 | 0.21 | 110 | 750 | 550 | 320 | 22 |
CI, confidence interval; Vi, apparent volumes of distribution in central compartment (i = 1), peripheral compartment (i = 2), and at steady-state (i = ss); ki, first-order rate constant for distribution (i = 12), redistribution (i = 21), and elimination (i = el).