Table 2.

Reported outcomes for Accelerated CXL in the literature (ACXL: Accelerated CXL, UCVA: uncorrected visual acuity, BCVA: Best corrected visual acuity).

Author	Type of Study	Study features	Results
Waszczykowska et al.	Prospective interventional case series	16 eyes with ACXL (6 mW/cm2 for 15 min) followed for 2 years	-Significant flattening of the cornea in 18.7% of patients with a higher preoperative Kmax value (>50 D) and corneal steepening in patients with a lower Kmax value (<50 D) -Persistent corneal haze in 25% of patients
Shetty et al.	Prospective randomized interventional study	138 eyes with four irradiation protocols (3, 9,18, and 30 mW/cm2) at one year follow up	-Better visual, refractive, and tomographic improvements in the conventional and irradiations of 9 mW/cm2 and 18 mW/cm2. -Greater flattening effect in the conventional method
Tomita et al.	Prospective comparative interventional case series	30 eyes with ACXL and 18 eyes with conventional CXL	-Shallower demarcation line in ACXL -Both methods appear to be safe and effective.
Kymionis et al.	Prospective comparative interventional case series	12 eyes with ACXL (9 mW/cm2 for 10 min) and 9 eyes with standard protocol	Deeper demarcation line in the conventional group
Hashemi et al.	Prospective randomized clinical trial	31 eyes with ACXL (18 mW/cm2 for 5 min) and 31 contralateral eyes with conventional method	Comparable in outcome, safety and stopping the progression Better corneal flattening in the conventional method
Chow et al.	Prospective comparative interventional case series	19 eyes with ACXL (18 mW/cm2 for 5 min) and 19 eyes with conventional method	No significant difference in the improvement of UCVA, BCVA, and spherical equivalent
Elbaz et al.	Retrospective comparative interventional case series	16 eyes with ACXL (9 mW/cm2 for 10 min) followed for 12 months	-Improvement in the UCVA -Stabilization of all tested corneal parameters
Kymionis et al.	Prospective comparative interventional case series	10 eyes with ACXL (9 mW/cm2 for 10 min) followed for 3 months	-No endothelial cell loss -No intraoperative or early postoperative complication
Hashemian et al.	Prospective comparative interventional case series	77 eyes with ACXL and 76 eyes with conventional method	BCVA, UCVA, refraction, maximum keratometry, endothelial cell density, anterior and posterior stromal keratocyte density, and subbasal nerve density all were comparable and acceptable in the two groups
Shetty et al.	Prospective comparative interventional case series	30 eyes below 14 years of age with ACXL followed for 24 months	Safe and effective procedure in pediatric patients
Bozkurt et al.	Prospective comparative interventional case series	47 eyes with ACXL (30 mW/cm2 for 3 min) followed for 24 months	Improved UCVA, BCVA, corneal topography, total HOA, and coma aberrations
Sadoughi et al.	Prospective randomized interventional study	15 eyes with ACXL (9 mW/cm2 for 10 min) and 15 contralateral eyes with conventional method	-Similar refractive, visual, keratometric, and aberrometric results -Less adverse effects on the corneal thickness and endothelial cells in ACXL

ACXL: Accelerated CXL; UCVA: Uncorrected visual acuity; BCVA: Best corrected visual acuity.