Table 1.
Acute preclinical toxicity test for NDHP in rats.
| Parameter |
Treatment |
||
|---|---|---|---|
| Control | NDHP (300 mg/kg) | NDHP (2000 mg/kg) | |
| Body weight(g) | |||
| Initial | 151 ± 4.50 | 154 ± 5.11 | 162 ± 3.50 |
| Final | 183 ± 4.48 | 182 ± 5.00 | 185 ± 6.46 |
| Organ to body weights(mg/g bw) | |||
| Liver | 38.6 ± 1.19 | 41.7 ± 1.42 | 38.4 ± 1.15 |
| Heart | 4.38 ± 0.18 | 4.16 ± 0.09 | 4.17 ± 0.19 |
| Kidneys | 8.23 ± 0.29 | 8.47 ± 0.22 | 8.24 ± 0.18 |
| Spleen | 2.71 ± 0.23 | 2.62 ± 0.12 | 2.59 ± 0.16 |
| Water intake(mL/rat/day) | 29.1 ± 0.56 | 30.6 ± 0.87 | 29.2 ± 0.90 |
| Food intake(g/rat/day) | 17.0 ± 0.30 | 17.6 ± 0.19 | 17.1 ± 0.46 |
Data are shown as mean ± SEM. n = 6 per group. *p < 0.05 compared to Control (vehicle; Cremophor 5%). For organ evaluation, values were expressed as organs index corresponding to division of organ weight (mg) by the body weight of the animal (g).