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. 2017 Dec 19;3:17046. doi: 10.1038/celldisc.2017.46

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Gene expression analysis of induced limb progenitor cells in comparison with embryonic limb bud. (a, b) Hierarchical clustering of Hox genes (a) and transcription factors related to embryonic limb development (b) in FBs, E10.5 fore- and hind-limb, control FB without differentiation (kept in MES-Lif), and 2c-iPSCs. (c) Expression levels of selected genes involved in the determination and development of embryonic limb, showing that these genes were induced in differentiated FBs, but not in control or iPSCs.