Table 2.
Chromosomal Changes Associated with MLS Resistance Among Isolates Not Containing ermB and/or mef (n = 37)
| Year | Strain ID | Serotype | ERY | CLDa | Q-Db | Changes in L4c,d | Changes in L22c,d | Changes in 23S rRNAc | Othere |
|---|---|---|---|---|---|---|---|---|---|
| 1999 | 3802-99 | 19A | > 32 | 0.12 | 1.5 | 69GTG71 to TPS, E13Q, E30Q, V88I, G98A, A128S, S130E | |||
| 1999 | 6275-99 | 19A | > 32 | 0.06 | 0.5 | 69GTG71 to TPS, E13Q, E30Q, V88I, G98A, A128S, S130E | |||
| 2002 | 5087-03 | 19A | > 32 | 0.12 | 1 | 69GTG71 to TPS, E13Q, E30Q, V88I, G98A, A128S, S130E | |||
| 2002 | 5486-02 | 23F | 2 | < 0.03 | 1 | E30K 63KPWRQKTGTGRA73 | |||
| 2002 | 5001-02 | 22F | 2 | 0.12 | 8 | S112L | 102KRTAHITRTAHIVA110 | ||
| 2005 | 5309-05 | 22F | 4 | 0.06 | 24 | S112L | 102KRTAHITKRTAHITVA110 | ||
| 2007 | 6466-07 | 19A | 16 | 0.25 | > 32 | 85PMKRFRPPMKRFRPR92T85P | |||
| 1999 | 2009219579 | 35F | 2 | 0.12 | 0.5 | A2061G | |||
| 1999 | 3494-00 | 19A | 16 | 0.5 | 1 | A2061G | |||
| 1999 | 4397-99 | 004 | 32 | 1 | 1 | A2061G | |||
| 1999 | 1361-00 | 06B | > 32 | 1 | 1 | A2061G | |||
| 1999 | 4056-00 | 06B | > 32 | 2 | 1.5 | A2061G | |||
| 1999 | 7783-99 | 09N | > 32 | 2 | 1 | A2061G | |||
| 1999 | 5667-99 | 06B | > 32 | > 2 | 2 | A2061G | |||
| 2003 | 6752-04 | 10A | > 32 | 0.25 | 1 | A2061G | |||
| 2003 | 8297-04 | 35B | > 32 | 2 | 1 | A2061G | |||
| 2004 | 9764-04 | 034 | 32 | 1 | 1 | A2061G | |||
| 2005 | 3662-06 | 06C | > 32 | > 2 | 1.5 | A2061G | |||
| 2005 | 7853-05 | 06A | > 32 | 2 | 2 | A2061G | |||
| 2006 | 5473-07 | 22F | > 32 | 2 | 2.0 | S112L | A2061G | ||
| 2006 | 6549-07 | 17F | 32 | 1 | 0.5 | A2061G | |||
| 2006 | 7509-06 | 15C | > 32 | > 2 | 2 | A2061G | |||
| 2006 | 8043-06 | 23A | > 32 | 2 | 1.5 | A2061G | |||
| 2007 | 2010200843 | 09N | 32 | 1 | 2 | A2061G | |||
| 2007 | 7948-07 | 034 | > 32 | > 2 | 1.5 | A2061G | |||
| 2007 | 2008008613 | 19A | 32 | 1 | 1 | ermA + | |||
| 2006 | 7541-06 | 003 | > 32 | 2 | 1 | ermA + | |||
| 2004 | 4336-05 | 038 | 2 | 0.12 | 0.5 | ermA + | |||
| 1999 | 6306-99 | 24F | 16 | 1 | 0.5 | None | |||
| 2006 | 7582-06 | 23A | 32 | 2 | 1 | None | |||
| 2003 | 7995-03 | 07F | 16 | 0.12 | 0.5 | None | |||
| 1999 | 4066-00 | 014 | 16 | 1 | 1 | None | |||
| 2006 | 4882-07 | 07F | 4 | 0.12 | 0.5 | None | |||
| 2006 | 7701-07 | 35F | > 32 | 2 | 1.5 | None | |||
| 2003 | 2003000312 | 10A | > 32 | 2 | 2 | None | |||
| 2002 | 2009214597 | 06A | > 32 | 1 | 0.5 | None | |||
| 1999 | 5272-03 | 001 | 8 | 0.25 | 0.5 | None |
a
Clindamycin resistance was not inducible in any of the clindamycin-susceptible strains.
b
Determined by Etest.
c
Relative to TIGR4.
d
Insertions are underlined.
e
ermT, ermA (subclass ermTR), cfr, lsaC, and vgaA.
CLD, clindamycin; ERY, erythromycin; MLS, macrolides/lincosamides/streptogramin; Q-D, quinupristin–dalfopristin (Synercid).