Table 3.
Changes Associated with Quinupristin–Dalfopristin Nonsusceptibility
| Year | Strain ID | Serotype | ERY | CLD | Q-Da | Changes in L4c,d | Changes in L22c,d | Changes in 23S rRNAc | Othere |
|---|---|---|---|---|---|---|---|---|---|
| 1997 | 3179-97 | 09V | 4 | 0.12 | 2.0 | ||||
| 1997 | 1095-99 | 11A | > 8 | 4 | 2.0 | A2060C | |||
| 2007 | 2008236056 | 19A | > 32 | > 2 | 2.0 | e + m | |||
| 2007 | 2008227074b | 09N | 1 | 0.06 | 3.0 | Q67R R72G | |||
| 2000 | 4339-00 | 19F | 0.5 | 0.06 | 4.0 | 63KPWRQKGKGTGRAR74 | |||
| 2001 | 5663-01 | 19F | 32 | 0.06 | 4.0 | 63KPWRQKGSQKGTGRAR74 | m | ||
| 2003 | 6766-04 | 12F | 0.25 | ≤ 0.03 | 4.0 | 63KPWRPWRQKGTGRAR74 | |||
| 2008 | 2008237895 | 07F | 0.5 | 0.06 | 4.0 | 78AFANEGPTIAFANEGPTM86 | |||
| 2000 | 7697-03 | 23F | 1 | 0.12 | 8.0 | E30K | |||
| 2001 | 2009216547 | 014 | 2 | 0.06 | 8.0 | 102KRTAHITRTAHITVA110 | |||
| 2001 | 6434-01 | 06A | 2 | 0.06 | 8.0 | 102KRTAHITKRTAHIVA110 | |||
| 1996 | 0571-97 | 004 | 1 | 0.06 | 12.0 | 102KRTAHITKRTAHITVA110 | |||
| 2007 | 7799-07 | 11A | > 32 | 1 | 12.0 | C2613G | |||
| 2010 | 2010223420 | 19A | 4 | 0.06 | 12.0 | 102KRTAHITVRTAHITVA110 | |||
| 2008 | 2009208197 | 16F | 1 | 0.06 | 16.0 | 85TMKRFRPRASFRPRAK94 | |||
| 2000 | 6356-00 | 06A | 4 | 0.06 | 32.0 | R103C | |||
| 1995 | 3262-95 | 06A | 2 | ≤ 0.03 | 12.0 | None | |||
| 2001 | 5951-01 | 004 | 1 | 0.06 | 8.0 | None |
a
Determined by Etest.
b
This strain is nonsusceptible to linezolid (minimum inhibitory concentration = 4 μg/ml).
c
Relative to TIGR4.
d
Insertions are underlined.
e
ermT, ermA (subclass ermTR), ermB (e), mef (m), cfr, lsaC, and vgaA.