Table 3.
IrAEs related to Interleukin-2 |
1. 70% low level requiring no to minimal intervention |
a. Vitiligo in mM patients |
b. Thyroid dysfunction: 3 times more common in mRCC than mM |
2. <5% irAEs reported requiring intervention (holding IL-2) |
a. joint pain |
b. Neuropathy |
c. Hepatitis by enzyme elevation |
15 Serious irAEs reported in overall Data Base among 152 irAEsa |
6 in patients with mRCC – all during IL-2 |
9 in mM patients – 4 during IL-2; 5 after IL-2 |
9 patients - Myocarditis – all during IL-2 |
7 patients, only enzyme release; no clinical, electrocardiogram or echocardiogram findings |
2 patients – elevated enzymes; 1- abnormal electrocardiogram and symptoms; 1 – elevated enzymes and asymptomatic ventricular arrhythmia. |
1 patient each - Myasthenia Gravis, Guillain Barre - both related to IL-2 |
4 serious irAEs reported related to CPIa: 1 each: colitis, encephalopathy, neuropathy, uveitis |
airAEs related to CPI were not required to be reported