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. 2017 Dec 19;5:101. doi: 10.1186/s40425-017-0308-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — CB-1158 combines with gemcitabine to inhibit tumor growth. a CB-1158 in combination with gemcitabine treatment in the CT26 model (left), the LLC model (center), or the 4T1 model (right) inhibited tumor growth. N = 10 per group. b On study day 14, CT26 tumors from animals treated with CB-1158 and gemcitabine had decreased myeloid cells (upper left), increased NK cells (upper right), decreased suppressive macrophages (lower left), and increased inflammatory macrophages (lower right) as determined by flow cytometry compared to vehicle-treated animals