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. 2017 Dec 19;16:159. doi: 10.1186/s12933-017-0640-5

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Enrollment of diabetic patients taking metformin plus DPP-4 inhibitor versus other hypoglycemic agents. A total of 16,017 diabetic patients taking metformin plus DPP-4 inhibitor are compared with 74,863 patients prescribed other hypoglycemic agents (including sulfonylurea, alpha glucosidase inhibitor, thiazolidinedione, meglitinide, insulin, or glucagon-like peptide 1). AF atrial fibrillation, DM diabetes mellitus, DPP4i dipeptidyl peptidase-4 inhibitor, HA hypoglycemic agent