Table 4.
Studies comparing cognitive outcomes between GPi and STN DBS in PD patients.
| Author, year | N STN/GPi | Laterality | F/u (mo) | Status of stimulation/medication at cognitive assessment | Cognitive measures assessed | Differences between GPI and STN |
|---|---|---|---|---|---|---|
| Boel et al., 2016 [55] | 63/65 | BL | 36 | ON/ON | GC, A/C, E, M, L | None |
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| Follett et al., 2010 [52] | 147/152 | BL | 24 | ON/OFF | GC, L, V, E, M | None |
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| Odekerken et al., 2013 [26] | 63/65 | BL | 12 | ON/integrated ON and OFF | Composite test | None |
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| Odekerken et al., 2015 [54] | 56/58 | BL | 12 | ON/ON | A/C, E, M, L, V | 4/11 measures of A/C worse with STN |
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| Odekerken et al., 2016 [34] | 43/47 | BL | 36 | ON/ON | A/C, E, M, composite score | None |
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| Okun et al., 2009 [51] | 22/23 | UL | 7 | ON/OFF | L | None |
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| Rothlind et al., 2007 [50] | 19/23 | UL | 6 | ON/ON | A/C, E, L, V, M | None |
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| Rothlind et al., 2007 [50] | 14/15 | BL | 21 | ON/ON | A/C, E, L, V, M | None |
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| Rothlind et al., 2015 [47] | 84/80 | BL | 6 | ON/ON | A/C, E, GC, L, M | None overall, E worse with STN, M worse with Gpi |
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| Weaver et al., 2012 [53] | 70/89 | BL | 36 | ON/OFF | GC, L, V, E, M | M worse with STN |
PD: Parkinson's disease; GPi: globus pallidus interna; STN: subthalamic nucleus; N: number of patients; mo: months; UL: unilateral; BL: bilateral; A/C: attention/concentration; E: executive; GC: global cognition; L: language; M: memory; V: visual. Adapted from Mehanna [101] with permission from the author.