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SERINC3 and SERINC5 isoforms. SERINC3 does not have isoforms and is transported directly to the cell membrane. SERINC5 protein has five isoforms generated by alternative splicing. These differ at the terminal carbon end and in the transmembrane domains. The SERINC5-001 isoform has 10 transmembrane domains, only these are in the cell membrane and are involved in the inhibition of HIV infectivity.
