Appendix.

Summary of Adult Ketamine Indication-Specific, Evidence-Based Dosing Ranges in ED.

Indication	Dosing	Order default dosing
Analgesia	Bolus (ie, subdissociative dosing) 0.15 mg/kg, up to <1 mg/kg IV Alternatively, 1.5-2 mg/kg IM Repeat dosing (assess after 30 minutes) 0.15-0.3 mg/kg IV 1.5 mg/kg IM	0.3 mg/kg IV or 1.5 mg/kg IM
Rapid sequence intubation	Bolus: 1-2 mg/kg IV Repeat dose if adequate sedation not achieved: 0.5-1 mg/kg IV	1 mg/kg IV
Procedural sedation	Bolus 1-2 mg/kg IV (If given with concomitant propofol, give 0.5-0.75 mg/kg IV) Alternatively, 3-5 mg/kg IM Repeat dosing (if necessary) 0.5-1 mg/kg IV every 5-10 minutes as needed Repeat dosing (if necessary—10 minutes after initial dose) 2-4 mg/kg IM	1 mg/kg IV or 4 mg/kg IM

Note. ED = emergency department; IV = intravenous; IM = intramuscular.