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. 2017 Dec 19;15:54. doi: 10.1186/s12964-017-0210-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Associations between IL6/IL6R expression and the clinic-pathologic features of gliomas. a–b The expression of IL6R (a) and IL6 (b) were shown according to molecular subtypes of TCGA gliomas. c–d The expression of IL6R (c) and IL6 (d) were shown according to IDH status of TCGA gliomas. e–f Prognostic significance of IL6R in TCGA gliomas (e) and GBMs (f). g The prognostic significance of IL6R was validated in REMBRANDT gliomas. h–i Prognostic significance of IL6 in TCGA gliomas (h) and GBMs (i). j The prognostic significance of IL6 was confirmed in REMBRANDT gliomas. ***P < 0.001. Classical, CL; neural, NE; proneural, PN; mesenchymal, ME