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. 2017 Dec 19;14:252. doi: 10.1186/s12974-017-1004-5

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Effects of D-NAC on neurobehavioral outcomes and survival in Mecp2-null mice. a Twice weekly injections of 10 mg/kg doses of D-NAC treatment significantly improved the composite behavioral score compared to vehicle (PBS)-injected Mecp2-null mice (*p < 0.05). There was a trend for the composite behavioral score to be lower in NAC-treated Mecp2-null mice (p = 0.07). b Survival was assessed using a Kaplan-Meier curve. D-NAC did not improve survival compared to PBS-treated animals. D-NAC-treated Mecp2-null mice showed a trend for longer survival time (p = 0.06) compared to NAC-treated mice