Fig. 2.

Model training and validation. The ODE model was trained to match experimental measurements of activated species in the TSP1-mediated apoptosis signaling pathway. (a) TSP1:CD36:p59fyn [12]; (b) pp59fyn [12]; (c) pp38MAPK [12]; (d) caspase-3 activity [12]; and (e) caspase-3 activity [15]. (f) An independent set of data for caspase-3 activity under the condition of p38MAPK inhibition [12] was used to validate the model prediction. Solid line: mean of 12 best fits. Shaded area: 95% confidence interval. Squares: experimental data