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. 2017 Dec 19;15:53. doi: 10.1186/s12964-017-0207-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Distribution of cPARP concentration in population-level model. a-d: Histogram showing the percentage of the 2000 cells with a given cPARP concentration, in response to 10 nM TSP1 stimulation. (a) Baseline model; (b) XIAP downregulation; (c) DXR treatment; and (d) Increased nuclear translocation rate. A different color is assigned to each time point. The cPARP threshold is marked by a solid line and the region in the x-y plane beyond the threshold is shaded as light purple. (e-h): The predicted percentage of non-apoptotic (black) and apoptotic (purple) cells in response to 10 nM TSP1 stimulation. (e) Baseline model; (f) XIAP downregulation; (g) DXR treatment; and (h) Increased nuclear translocation rate