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. 2017 Dec 19;15:53. doi: 10.1186/s12964-017-0207-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Relationship between initial conditions and predicted apoptotic response. (a) Initial concentrations of PARP and XIAP for apoptotic cells (purple) and non-apoptotic cells (grey). The difference between the initial amounts of PARP and XIAP is larger for apoptotic cells, which reach higher cPARP levels. (b) Histogram showing distribution of initial XIAP concentration for apoptotic cells (purple) and non-apoptotic cells (grey). The apoptotic cells have relatively lower initial XIAP concentrations. (c) Histogram showing distribution of initial PARP concentrations for apoptotic cells (purple) and non-apoptotic cells (grey). The apoptotic cells have higher initial PARP concentrations