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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Trends Biochem Sci. 2017 Sep 27;42(11):862–872. doi: 10.1016/j.tibs.2017.09.003

Figure 1. Coactivator binding stimulates TEAD transcriptional activity.

Figure 1

YAP/TAZ and VGLL competitively bind TEAD to regulate its transcriptional activity. When the Hippo pathway is “off” YAP/TAZ are dephosphorylated and translocated to the nucleus to bind TEAD and activate transcription of downstream target genes. Abundance of nuclear YAP/TAZ outcompetes VGLL-TEAD binding. When the Hippo pathway is “on”, YAP/TAZ are phosphorylated and sequestered in the cytoplasm. Absence of YAP/TAZ in the nucleus allows VGLL-TEAD binding.