Skip to main content
. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Trends Biochem Sci. 2017 Sep 27;42(11):862–872. doi: 10.1016/j.tibs.2017.09.003

Figure 2. Osmotic stress promotes p38-mediated TEAD cytoplasmic localization.

Figure 2

Under conditions of normal osmolarity, TEAD is localized in the nucleus and its activity is regulated by the nuclear-cytoplasmic shuttling of YAP/TAZ. Under conditions of osmotic stress: 1) p38 is activated and binds to TEAD; 2) the p38-TEAD complex translocates to the cytoplasm; 3) In cancers in which YAP is constitutively dephosphorylated and localized in the nucleus, cytoplasmic translocation of TEAD results in the inability to retain nuclear YAP/TAZ.