Table 1.

TEADs in disease

Disease	Gene	Alteration (mutation or expression)	Effects	Target gene	Reference
Sveinsson’s chorioretinal atrophy	TEAD1	Y421H inactivating mutation	choroidal and retinal degeneration		14
Breast cancer, squamous cell carcinoma	TEAD4	increased expression	increased cell proliferation and tumorigenesis, decreased survival		42
Prostate cancer	TEAD1	increased expression	decreased survival		62
Breast cancer	TEAD4	increased expression			63
Breast cancer	TEAD2	increased expression	EMT	zyxin	65
Colorectal cancer	TEAD2, TEAD4	increased expression	EMT, correlated with decreased survival	vimentin	66
Cervical cancer, breast cancer	TEAD1		resistance to apoptosis	livin	67
Pancreatic cancer	TEAD1	increased expression		mesothelin	68
Melanoma	TEAD4		increased invasiveness, resistance to MAPK inhibition		69