Table 2.
Hazard ratios (HR) and 95% CI for associations of lipid biomarkers with total cancer mortality
| Biomarker | quartile_1 | quartile_2 | quartile_3 | quartile_4 | pval_med | hr_con | pval_con |
|---|---|---|---|---|---|---|---|
| TCa | Ref | 0.78 (0.60–1.00) | 0.78 (0.61–1.01) | 0.77 (0.59–0.99) | 0.072 | 0.67 (0.47–0.95) | 0.025 |
| TC adjustedb | Ref | 0.74 (0.56–0.98) | 0.77 (0.59–1.02) | 0.71 (0.54–0.94) | 0.036 | 0.62 (0.43–0.88) | 0.009 |
| Medianc | 4.70/4.70/4.60 | 5.50/5.60/5.50 | 6.20/6.20/6.20 | 7.20/7.20/7.10 | |||
| No of cases | 187 | 158 | 170 | 177 | |||
| HDL-Ca | Ref | 0.83 (0.66–1.03) | 0.86 (0.69–1.08) | 0.56 (0.43–0.73) | <0.0001 | 0.67 (0.55–0.82) | 0.0001 |
| HDL-C adjustedb | Ref | 0.93 (0.73–1.18) | 0.95 (0.74–1.22) | 0.67 (0.50–0.91) | 0.021 | 0.78 (0.62–0.98) | 0.037 |
| Medianc | 0.95/0.90/1.20 | 1.20/1.10/1.50 | 1.50/1.40/1.80 | 2.00/1.80/2.10 | |||
| No of cases | 254 | 188 | 188 | 103 | |||
| apo(a)a | Ref | 0.77 (0.60–0.97) | 0.75 (0.59–0.95) | 0.64 (0.50–0.82) | 0.0007 | 0.56 (0.39–0.80) | 0.001 |
| apo(a) adjustedb | Ref | 0.76 (0.58–0.99) | 0.80 (0.62–1.03) | 0.71 (0.54–0.93) | 0.029 | 0.67 (0.45–0.99) | 0.044 |
| Medianc | 1.34/1.30/1.48 | 1.54/1.48/1.68 | 1.70/1.64/1.90 | 2.04/1.91/2.16 | |||
| No of cases | 224 | 169 | 183 | 156 | |||
| apoB-100a | Ref | 0.84 (0.66–1.08) | 0.73 (0.56–0.94) | 0.87 (0.68–1.12) | 0.284 | 0.82 (0.64–1.05) | 0.112 |
| apoB-100 adjustedb | Ref | 0.88 (0.68–1.15) | 0.69 (0.52–0.91) | 0.79 (0.60–1.03) | 0.054 | 0.72 (0.56–0.93) | 0.011 |
| Medianc | 0.82/0.84/0.77 | 1.03/1.07/0.97 | 1.21/1.26/1.15 | 1.47/1.53/1.38 | |||
| No. of cases | 173 | 178 | 160 | 204 | |||
| TGa | Ref | 1.29 (1.00–1.67) | 1.00 (0.77–1.29) | 1.21 (0.94–1.56) | 0.382 | 1.06 (0.95–1.19) | 0.305 |
| TG adjustedb | Ref | 1.28 (0.97–1.70) | 0.92 (0.69–1.23) | 1.10 (0.82–1.46) | 0.895 | 0.97 (0.85–1.11) | 0.675 |
| Medianc | 0.90/1.00/0.80 | 1.50/1.70/1.10 | 2.00/2.40/1.60 | 3.30/3.70/2.70 | |||
| No of cases | 153 | 173 | 162 | 200 | |||
| Lp(a)a | Ref | 0.98 (0.77–1.25) | 0.76 (0.59–0.98) | 0.78 (0.60–1.00) | 0.080 | 0.94 (0.90–0.99) | 0.011 |
| Lp(a) adjustedb | Ref | 0.94 (0.72–1.22) | 0.73 (0.56–0.96) | 0.74 (0.57–0.98) | 0.076 | 0.94 (0.89–0.98) | 0.010 |
| Medianc | 3.50/3.30/3.85 | 8.50/8.10/9.40 | 20.25/19.40/21.75 | 129.60/121.60/134.70 | |||
| No of cases | 189 | 187 | 160 | 157 |
aCrude model adjusted for sex and age at blood draw
bMultivariable model further adjusted for baseline height, waist, BMI, lifetime alcohol consumption, red meat intake, fiber intake, smoking status, socioeconomic status, physical activity, diabetes, hypertension, and use of lipid-lowering drugs
cMedians of lipid parameters are of all/men/women within the cancer deaths
Entries in boldface are statistically significant
apo apolipoprotein, CI confidence interval, HDL-C high-density lipoprotein, hr_con continuous HR for a doubling in biomarker concentration, Lp(a) lipoprotein (a), pval_con P trend continuously, pval_med P trend over lipid biomarker levels based on the median of each quartile, TC total cholesterol, TG triglycerides