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. 2017 Dec 19;8:283. doi: 10.1186/s13287-017-0739-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Transplantation of hAD-MSCs improves ovarian function in POI rats. a Vaginal smears were obtained and the estrous cycles were evaluated by H&E staining. Representative photographs for estrus, proestrus, metestrus, and diestrus are shown (100×). b The percentage of rats with abnormal cyclicity was detected at 1, 4, and 8 weeks after cell transplantation. c–e Serum levels of AMH (c), E2 (d), and FSH (e) were detected at 0, 2, 4, 6, 8, and 10 weeks after cell transplantation. Scale bars = 100 μm. *P < 0.05, **P < 0.01. AMH anti-Müllerian hormone, FSH follicle-stimulating hormone, hAD-MSCs human adipose-derived mesenchymal stem cells, LIPUS low-intensity pulsed ultrasound, POI primary ovarian insufficiency