Table 3.
Enriched functions of DE genes in the Down and Up group using DAVID (89% grain vs. 72% grain)
| GO terms | P value | Molecules |
|---|---|---|
| Down Group | ||
| Down-regulated genes (n = 45) | ||
| GO:0045087~innate immune response | 8.2E-05 | EIF2AK2, MX1, S100A9, C2, NLRC5, C1QB |
| GO:0042742~defense response to bacterium | 1.2E-04 | ISG15, CXCL5, TAP |
| GO:0006958~complement activation, classical pathway | 2.7E-04 | C3, C2, C1QB |
| GO:0051607~defense response to virus | 9.8E-04 | OAS1Y, ISG15, MX1, NLRC5 |
| GO:0045071~negative regulation of viral genome replication | 1.2E-03 | EIF2AK2, ISG15, MX1 |
| GO:0009636~response to toxic substance | 2.4E-03 | EIF2QK2, CYP1A1, CYP1B1 |
| GO:0009404~toxin metabolic process | 1.1E-02 | CYP1A1, CYP1B1 |
| GO:2,000,427~positive regulation of apoptotic cell clearance | 1.5E-02 | C3, C2 |
| GO:0006956~complement activation | 1.8E-02 | C3, C2 |
| GO:0034340~response to type I interferon | 2.2E-02 | ISG15, MX1 |
| GO:0006955~immune response | 2.2E-02 | OAS1Y, CXCL5, LOC504773 |
| GO:0070098~chemokine-mediated signaling pathway | 4.7E-02 | CXCL5, LOC504773 |
| Up-regulated genes (n = 22) | ||
| GO:0035914~skeletal muscle cell differentiation | 3.2E-02 | EGR1, FOS |
| Up Group | ||
| Down-regulated genes (n = 163) | ||
| GO:0051301~cell division | 4.4E-09 | SKA3, ASPM, CKS2, PTTG1, CCNB1, BIRC5, CCNB2, AURKA, SPC24, NCAPH, UBE2C, CCNA2, CDCA3, SPDL1, TPX2 |
| GO:0007080~mitotic metaphase plate congression | 6.0E-05 | KIF22, KIFC1, CDCA8, KIF2C, CCNB1, SPDL1 |
| GO:0007018~microtubule-based movement | 1.1E-04 | KIF22, KIFC1, KIF2C, KIF11, KIF20A, CENPE |
| GO:0007059~chromosome segregation | 3.1E-04 | SKA3, SLC25A5, KIF11, CENPT, BIRC5, HJURP |
| GO:0007067~mitotic nuclear division | 3.8E-04 | PLK1, SKA3, ASPM, CCNA2, PTTG1, CCNB2, NUF2, SPC24 |
| GO:0031577~spindle checkpoint | 6.1E-04 | AURKB, BIRC5, SPDL1 |
| GO:0045143~homologous chromosome segregation | 6.1E-04 | PLK1, ESPL1, PTTG1 |
| GO:0000070~mitotic sister chromatid segregation | 1.4E-03 | PLK1, CDCA8, ESPL1, SPAG5 |
| GO:0051988~regulation of attachment of spindle microtubules to kinetochore | 2.0E-03 | RACGAP1, ECT2, SPAG5 |
| GO:0007052~mitotic spindle organization | 2.7E-03 | AURKB, CCNB1, NDC80, AURKA |
| GO:0000281~mitotic cytokinesis | 4.1E-03 | PLK1, RACGAP1, KIF20A, CKAP2 |
| GO:0090307~mitotic spindle assembly | 5.3E-03 | KIFC1, KIF11, BIRC5, TPX2 |
| GO:0034501~protein localization to kinetochore | 5.4E-03 | AURKB, SPDL1, BUB1B |
| GO:0010628~positive regulation of gene expression | 6.7E-03 | MAPK11, CAV1, ACTA2, FN1, ACTG2, VIM |
| GO:0000910~cytokinesis | 8.0E-03 | CIT, KIF20A, BIRC5, ECT2 |
| GO:0007094~mitotic spindle assembly checkpoint | 1.2E-02 | PLK1, BUB1B, BUB1 |
| GO:0071346~cellular response to interferon-gamma | 1.9E-02 | SLC26A6, GAPDH, LOC504773 |
| GO:0001578~microtubule bundle formation | 2.4E-02 | PLK1, KIF20A, TPPP3 |
| GO:0006096~glycolytic process | 2.7E-02 | GAPDH, ENO1, ENO2 |
| GO:0035606~peptidyl-cysteine S-trans-nitrosylation | 2.8E-02 | GAPDH, S100A9 |
| GO:0006816~calcium ion transport | 3.9E-02 | CAV1, ANXA6, CACNA1G |
| GO:0045931~positive regulation of mitotic cell cycle | 3.9E-02 | CCNB1, BIRC5, CDC25B |
| Up-regulated genes (n = 122) | ||
| GO:0043507~positive regulation of JUN kinase activity | 1.4E-02 | FZD5, EDN1, EPHA4 |
| GO:2,001,237~negative regulation of extrinsic apoptotic signaling pathway | 2.6E-02 | PHIP, ITGAV, TGFBR1 |
| GO:0009404~toxin metabolic process | 2.9E-02 | CYP1A1, CYP1B1 |
| GO:0018406~protein C-linked glycosylation via 2′-alpha-mannosyl-L-tryptophan | 2.9E-02 | DPY19L3, DPY19L4 |
| GO:0002904~positive regulation of B cell apoptotic process | 2.9E-02 | FNIP1, CD24 |
| GO:0042632~cholesterol homeostasis | 3.0E-02 | CD24, ABCA1, EPHX2 |
| GO:0017144~drug metabolic process | 3.8E-02 | CYP1A1, FMO5 |
| GO:0045944~positive regulation of transcription from RNA polymerase II promoter | 4.1E-02 | PHIP, TET2, FZD5, EDN1, CCNT1, FOS, NRIP1, MYSM1, PCGF5 |