Table 4.
Enriched ingenuity canonical pathways of DE genes in the Down and Up group using IPA (89% grain vs. 72% grain)
| Ingenuity canonical pathways | -log (p-Value) | z-score | Molecules |
|---|---|---|---|
| Down group | |||
| Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses | 3.42E + 00 | −2.0 | CXCL8, OAS1, C3, IL1B, C1QB, EIF2AK2 |
| TREM1 Signaling | 2.59E + 00 | −2.0 | CXCL8, NLRC5, IL1B, FCGR2B |
| Up group | |||
| PTEN Signaling | 6.06E-01 | −2.0 | TGFBR1, NTRK2, FLT1, KRAS |
| Renin-Angiotensin Signaling | 9.28E-01 | 1.6 | FOS, MAP3K1, GNAQ, KRAS, MAPK11, FRS2 |
| IL-8 Signaling | 8.71E-01 | 1.6 | RAB11FIP2, CXCL8, FOS, FLT1, ITGAV, KRAS, FRS2 |
| ERK5 Signaling | 9.19E-01 | 2.0 | IL6ST, FOS, GNAQ, KRAS |
| JAK/Stat Signaling | 8.00E-01 | 2.0 | FOS, GNAQ, KRAS, FRS2 |
| NF-κB Activation by Viruses | 7.90E-01 | 2.0 | MAP3K1, ITGAV, KRAS, FRS2 |
| VEGF Family Ligand-Receptor Interactions | 7.76E-01 | 2.0 | FOS, FLT1, KRAS, FRS2 |
| Rac Signaling | 6.17E-01 | 2.0 | MAP3K1, PIKFYVE, KRAS, FRS2 |
| PKCθ Signaling in T Lymphocytes | 5.46E-01 | 2.0 | FOS, MAP3K1, KRAS, FRS2 |
| Role of NFAT in Regulation of the Immune Response | 4.09E-01 | 2.0 | FOS, GNAQ, KRAS, FRS2 |
| Cell Cycle: G2/M DNA Damage Checkpoint Regulation | 2.15E + 00 | 2.2 | CDC25B, CKS2, CCNB2, PLK1, AURKA, CCNB1 |
| PDGF Signaling | 9.28E-01 | 2.2 | FOS, MAP3K1, CAV1, KRAS, FRS2 |
| NF-κB Signaling | 7.60E-01 | 2.4 | TGFBR1, NTRK2, FLT1, MAP3K1, KRAS, FRS2 |