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. 2017 Dec 19;14:253. doi: 10.1186/s12974-017-1024-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 13 — CRT0066101 abrogates the secretion of pro-inflammatory cytokines and chemokines. PMM were cultured on 24-well plates and serum-starved overnight. The supernatants were collected after incubation with DMSO, DMSO plus LPA (1 μM), or LPA (1 μM) plus CRT (1 μM). ELISAs were used to quantitate IL-6, IL-1β, CXCL10 (IP-10), TNF-α, CXCL2 (MIP-2), and CCL5 (RANTES) concentrations. Results shown represent mean + SD from three independent experiments (N = 3) performed in triplicate (*p < 0.05, **p < 0.01, ***p < 0.001, compared to vehicle control; ^# p < 0.05, ^## p < 0.01, CRT + LPA compared to LPA-treated cells; one-way ANOVA with the Bonferroni correction)