Table 2.
Results are expressed as mean ± SD and analysed using one way ANOVA followed by bonferroni multiple comparison test for blood urea nitrogen, serum creatinine, serum albumin, albuminuria and proteinuria levels
| Normal Control | Vehicle Control | Diabetic Control | CR Control | CR + STZ | |
|---|---|---|---|---|---|
| Serum Parameters | |||||
| BUN (mg/dl) | 21 ± 2.24 | 17.6 ± 2.9 | 64.3 ± 8.4a | 34 ± 7.2a,b | 37.8 ± 6.6a,b |
| Creatinine (mg/dl) | 0.89 ± 0.141 | 0.9750 ± 0.119 | 1.73 ± 0.295a | 0.94 ± 0.064b | 1.17 ± 0.106b |
| Albumin (mg/dl) | 4.47 ± 0.418 | 4.1 ± 0.287 | 2.46 ± 0.691a | 2.9 ± 0.519a | 1.91 ± 0.218a# |
| Urine parameters | |||||
| Albumin (mg/24 h) | 77.00 ± 8.40 | 71 ± 9.70 | 551 ± 69a | 68 ± 11.10b | 78 ± 10b |
| Protein (mg/24 h) | 212 ± 60.10 | 223 ± 49.90 | 1351 ± 138.10a | 116.0 ± 41.40b | 115.20 ± 38.70b |
Carbohydrate restriction control (CR control), carbohydrate restriction + streptozotocin treated (CR + STZ). aVs Normal and vehicle control, bVs Diabetic control, # Vs CR control. P-value less than 0.05 (P < 0.05) was considered statistically significant.