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. 2017 Dec 15;9:903–913. doi: 10.2147/CMAR.S143110

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© 2017 Chen et al. This work is published and licensed by Dove Medical Press Limited

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Models show the possible metabolic status in thyroid cancer with different miR-34a expression. miR-34a expression in ATC was lower than that in differentiated thyroid carcinoma, which cannot inhibit the GLUT1 expression, leading to increased FDG avidity. The glycolysis pathway, including ¹⁸F-FDG uptake, was upregulated in patients with ATC. Thus, SUVmax was significantly higher in patients with ATC.

Abbreviations: ATC, anaplastic thyroid carcinoma; GLUT1, glucose transporter 1; FDG, fluorodeoxyglucose; SUVmax, maximum standardized uptake value; miRNA, microRNA.