Table 4.

Multinomial logistic regression—patient characteristics associated with whether the 41 561 women switched from or discontinued their index medication therapy

Predictor	Discontinued medication RRR (95% CI)	Switched to other therapies RRR (95% CI)
Index medication
LARC	0.14a (0.13–0.15)	0.36a (0.33–0.39)
LA	19.23a (11.32–32.64)	48.64a (28.69–82.46)
SARC	Ref	Ref
TA	4.64a (3.39–6.34)	4.29a (3.12–5.89)
Age, years
18–40	Ref	Ref
41–46	1.11b (1.03–1.20)	1.30a (1.21–1.41)
>46	1.76a (1.62–1.91)	1.46a (1.34–1.58)
Comorbidity
Anaemia	1.24a (1.15–1.34)	1.79a (1.65–1.93)
Inflammatory disease	1.43a (1.17–1.74)	1.29c (1.05–1.58)
Noninflammatory disease	1.09c (1.02–1.17)	0.86a (0.80–0.92)
Endometriosis	1.01 (0.87–1.18)	0.89 (0.76–1.04)
Benign neoplasm of uterus/ovary	1.00 (0.90–1.11)	0.67a (0.60–0.75)
Pregnancy/delivery	1.17 (0.94–1.44)	0.52a (0.41–0.66)
Enrollment time, years	1.37a (1.35–1.40)	1.39a (1.37–1.42)

ED, emergency department; LA, leuprolide acetate; LARC, long-acting reversible contraceptive steroid; Ref, reference; RRR, relative risk ratio; SARC, short-acting reversible contraceptive steroid; TA, tranexamic acid; UF, uterine fibroid.

^aP < 0.001;

^bP < 0.01;

^cP < 0.05.