Table 1.
Baseline Characteristics by Baseline BMI Group and by Baseline Diagnosis
| Characteristic | Overall | BMI < 18.5 | 18.5 ≤ BMI < 25 | 25 ≤ BMI < 30 | 30 ≤ BMI < 35 | BMI ≥ 35 | P-value |
|---|---|---|---|---|---|---|---|
| Normal Cognition at Baseline | |||||||
|
| |||||||
| N=5061 | N=49 | N=1759 | N=1981 | N=863 | N=409 | P-value | |
| Age, years, mean ± SD | 72.4 ± 8.2 | 75.8 ± 7.9 | 73.1 ± 8.7 | 72.6 ± 8.1 | 71.5 ± 7.8 | 69.6 ± 6.9 | < 0.001c |
| Education, years, mean ± SD | 15.7 ± 3.0 | 16.3 ± 2.5 | 16.1 ± 2.7 | 15.7 ± 3.0 | 15.3 ± 3.2 | 14.8 ± 3.3 | < 0.001c |
| Sex, n (% Female) | 3472 (69) | 44 (90) | 1294 (74) | 1214 (61) | 592 (69) | 328 (80) | < 0.001d |
| Race, n (% White) | 4113 (81) | 43 (88) | 1533 (87) | 1643 (83) | 651 (75) | 243 (59) | < 0.001d |
| Time in studya, years, mean ± SD | 4.1 ± 2.3 | 4.0 ± 2.3 | 4.2 ± 2.4 | 4.1 ± 2.3 | 3.9 ± 2.2 | 3.8 ± 2.2 | < 0.032c |
| Prevalent Co-Morbidities | |||||||
| Cardiovascular Disease, % present | 490 (10) | 7 (14) | 123 (7) | 205 (10) | 106 (12) | 49 (12) | 0.001d |
| Diabetes Mellitus, % present | 510 (10) | 0 (0) | 76 (4) | 179 (9) | 148 (17) | 107 (26) | < 0.001d |
| Congestive Heart Failure, % present | 60 (1) | 2 (1) | 15 (1) | 20 (1) | 13 (2) | 11 (3) | 0.082d |
| Systolic BP, mmHg, mean ± SD | 133 ± 18.0 | 132 ± 20.0 | 130 ± 18.0 | 133 ± 18.0 | 137 ± 17.0 | 139 ± 18.0 | < 0.001c |
| APOEε4 Status, n (% Positive)b | 1273 (30) | 16 (38) | 454 (31) | 497 (30) | 207 (29) | 99 (30) | 0.740d |
| FSRP, mean ± SD | 11.2 ± 4.5 | 12.0 ± 3.6 | 10.7 ± 4.6 | 11.2 ± 4.5 | 11.7 ± 4.5 | 11.9 ± 4.3 | < 0.001c |
|
| |||||||
| Mild Cognitive Impairment at Baseline | |||||||
|
| |||||||
| N=1879 | N=23 | N=721 | N=753 | N=274 | N=108 | P-value | |
|
| |||||||
| Age, years, mean ± SD | 74.5 ± 7.5 | 76.0 ± 6.7 | 75.2 ± 7.8 | 75.0 ± 7.3 | 73.9 ± 6.9 | 70.3 ± 7.3 | < 0.001c |
| Education, years, mean ± SD | 15.3 ± 3.3 | 15.4 ± 3.3 | 15.6 ± 3.2 | 15.4 ± 3.2 | 15.0 ± 3.5 | 13.5 ± 3.5 | < 0.001c |
| Sex, n (% Female) | 994 (82) | 22 (96) | 446 (62) | 319 (42) | 134 (49) | 73 (68) | < 0.001d |
| Race, n (% White) | 1535 (82) | 16 (70) | 623 (86) | 627 (83) | 209 (76) | 60 (56) | < 0.001d |
| Time in studya, years, mean ± SD | 3.3 ± 2.0 | 2.9 ± 2.2 | 3.4 ± 2.0 | 3.2 ± 2.0 | 3.3 ± 2.0 | 3.5 ± 2.0 | 0.120c |
| Prevalent Co-Morbidities | |||||||
| Cardiovascular Disease, % present | 266 (14) | 3 (13) | 92 (13) | 116 (15) | 42 (15) | 13 (12) | 0.580d |
| Diabetes Mellitus, % present | 235 (13) | 1 (4) | 51 (7) | 83 (11) | 57 (21) | 43 (40) | < 0.001d |
| Congestive Heart Failure, % present | 25 (1) | 0 (0) | 9 (1) | 8 (1) | 7 (3) | 1 (1) | 0.750d |
| Systolic BP, mmHg, mean ± SD | 136 ± 19.0 | 130 ± 15.0 | 134 ± 19.0 | 136 ± 19.0 | 139 ± 19.0 | 138 ± 19.0 | < 0.001c |
| APOEε4 Status†, n (% Positive)b | 747 (50) | 10 (62) | 310 (54) | 291 (49) | 98 (45) | 38 (44) | 0.048d |
| FSRP Score, mean ± SD | 12.3 ± 4.3 | 12.5 ± 4.1 | 12.1 ± 4.4 | 12.4 ± 4.2 | 12.8 ± 4.2 | 12.2 ± 4.3 | 0.140c |
a
Time in study from baseline visit to diagnostic outcome visit,
b
Percentages are calculated from N with non-missing values for APOE ε4 status that differs from total N in each BMI category,
c
Kruskal-WallisTest,
d
Pearson Test,
†
APOE (Apolipoprotein E) ε4 status, positive= ε2/ε4, ε3/ε4, or ε4/ε4, negative=ε2/ε2, ε2/ε3, or ε3/ε3 BMI=Body Mass Index; SD=Standard Deviation; FSRP=Framingham Stroke Risk Profile