Table 4.

Variables measured by questionnaire and measures obtained during the physical examination (extension of tables from ref 7)

Theme	Variables questionnaire	Outcomes	Physical examination
	Explanatory factors		Explanatory factors/outcomes
General	Demographic and ethnicity-specific factors: sex, age, marital status, household composition, country of birth of participant and his/her (grand)parents, self-reported ethnicity, migration history, educational level, occupational status, occupational level, religion, cultural distance (acculturation), ethnic identity, perceived ethnic discrimination (Everyday Discrimination Scale) Health-related behaviours: smoking, alcohol intake, cannabis use, physical activity (SQUASH questionnaire), weight perception, fruit intake, vegetarian diet, dietary pattern (breakfast, lunch and evening meal), coffee/tea intake, sugary drinks intake Healthcare use and related factors: subjectively measured health literacy (SBS-Q), compliance with medication, perceived quality of GP, healthcare use (GP, specialists, psychological care and alternative healthcare), healthcare use in country of origin Subsample*: dietary intake by extensive food frequency questionnaire (n≈5200)	Perceived general health, quality of life (SF-12), list of 20 chronic conditions, functional limitations (in those aged >55 years)	Anthropometry (weight, height and circumferences of waist, hip, thigh, arm and calf) Body fat percentage (using bioelectrical impedance) Hand grip strength Current medication use Subsamples*: physical activity by Actiheart accelerometer and heart rate monitor, 5 days (n≈500) objectively measured health literacy (REALM-D test) (n≈9700)
Cardiovascular health	History of high blood pressure/hypercholesterolaemia/ diabetes (including family history), family history of cardiovascular disease/sudden death, fainting history, age of menarche, age of menopause	Angina pectoris, possible myocardial infarction and intermittent claudication (by Rose questionnaire), self-reported and suspected myocardial infarction, self-reported and suspected cerebrovascular events	Blood pressure (sitting position, 5 min of rest, WatchBP Home, Microlife) Electrocardiogram (supine position, MAC 1600 System, GE Healthcare) Subsamples*: ankle-brachial blood pressure index (supine position, 7 min of rest, WatchBP Office ABI, Microlife) (n≈14600) arterial stiffness by oscillometrically measured pulse wave velocity (supine, 10 min of rest, Arteriograph) (n≈15000) non-invasive haemodynamics such as stroke volume, cardiac output, systemic vascular resistance (supine position, Nexfin) (n≈14500) glycocalyx measurement (under tongue, Glycocheck) (n≈6800)
Mental health	Perceived social support (DES subscale of SSQT with SSQS), childhood trauma, parental psychiatric history, mastery (Pearlin-Schooler Mastery Scale), neuroticism and extraversion (NEO Five Factor Inventory), stressful life events	Depressive symptoms (PHQ-9), nicotine use-related disorder (Fagerstrom), alcohol use-related disorder (AUDIT), cannabis use-related disorder (CUDIT)
Infectious diseases	History and presence of allergy/asthma/rhinitis, family history of allergy/asthma, food allergy, urogenital infections, travel behaviour, use of self-tests, history of blood transfusions, history of surgery in other countries, injecting drug use, sexual behaviour, use of contraceptives (women), vaccination against human papilloma virus (women), circumcision (men)		Self-reported current respiratory symptoms Self-reported vaginal hygiene (women)

*In subsamples, we strived for equal numbers in each ethnic group.

ABI, ankle-brachial index; AUDIT, Alcohol Use Disorders Identification Test; BP, blood pressure; CUDIT, Cannabis Use Disoreders Identification Test; DES, Daily Emotional Support subscale; GP, General practitioner; NEO, Neuroticism, Extraversion and Openness; PHQ-9, Patient Health Questionnaire-9; REALM-D, Rapid Estimate of Adult Literacy in Medicine in Dutch; SBS-Q, Chew’s Set of Brief Screening Questions; SF-12, 12-Item Short Form Survey; SQUASH, Short Questionnaire to Assess Health-enhancing physical activity; SSQS, Social Support Questionnaire for Satisfaction; SSQT, Social Support Questionnaire for Transactions;.