Table 3.
Outcome measures, combined RCT and PPT analysis
| Measure | Inpatient Groups 1 and 3 | Outpatient Groups 2 and 4 | P value* | ||
| n | n | ||||
| Reduction in PUQE score, mean (SD) | |||||
| 24 hours postpresentation | 76 | 4.7 (2.9) | 74 | 4.6 (3.0) | 0.769 |
| 48 hours postpresentation | 75 | 6.5 (3.5) | 71 | 6.6 (3.2) | 0.860 |
| 7 days postdischarge (compare presentation) | 61 | 5.3 (4.3) | 64 | 5.8 (4.1) | 0.478 |
| 7 days postdischarge (compare discharge) | 61 | −2.3 (3.9) | 64 | −1.5 (3.3) | 0.224 |
| Reduction in eating score, mean (SD) | |||||
| 24 hours postpresentation | 76 | 1.1 (1.2) | 74 | 1.0 (1.1) | 0.432 |
| 48 hours postpresentation | 76 | 1.8 (1.3) | 71 | 1.7 (1.1) | 0.687 |
| 7 days postdischarge (compare presentation) | 61 | 1.6 (1.4) | 64 | 2.0 (1.3) | 0.122 |
| 7 days postdischarge (compare discharge) | 61 | −0.5 (1.3) | 64 | 0.0 (1.2) | 0.025 |
| Reduction in drinking score, mean (SD) | |||||
| 24 hours postpresentation | 76 | 1.1 (1.3) | 74 | 1.0 (1.1) | 0.688 |
| 48 hours postpresentation | 76 | 1.7 (1.3) | 71 | 1.7 (1.2) | 0.769 |
| 7 days postdischarge (compare presentation) | 61 | 1.5 (1.4) | 64 | 2.1 (1.2) | 0.013 |
| 7 days postdischarge (compare discharge) | 61 | −0.5 (1.2) | 64 | 0.1 (1.2) | 0.006 |
| Improvement in well-being rating, mean (SD) | |||||
| 24 hours postpresentation | 76 | −3.2 (2.3) | 74 | −2.7 (2.3) | 0.196 |
| 48 hours postpresentation | 76 | −4.3 (3.2) | 71 | −4.5 (2.4) | 0.627 |
| 7 days postdischarge (compare presentation) | 61 | −4.1 (3.2) | 64 | −4.4 (2.6) | 0.475 |
| 7 days postdischarge (compare discharge) | 62 | 1.2 (2.7) | 64 | 0.4 (2.4) | 0.054 |
| Reduction in ketonuria, mean (SD) | |||||
| 24 hours postpresentation | 76 | 1.8 (1.4) | 74 | 1.9 (1.3) | 0.695 |
| 48 hours postrecruitment | 62 | 2.8 (1.5) | 56 | 3.0 (1.3) | 0.468 |
| Change in weight (kg), mean (SD) | |||||
| Presentation to 7 days postdischarge | 50 | 0.0 (2.7) | 50 | −0.1 (3.1) | 0.962 |
| Discharge to 7 days postdischarge | 49 | −0.6 (1.6) | 48 | -0.5 (0.5) | 0.789 |
| Duration of index presentation (days), median (IQR) | 75 | 2 (2) | 74 | 2 (1) | 0.941 |
| Reattendance within 7 days of discharge†, n (%) | 66 | 20 (30.3) | 71 | 18 (25.4) | 0.518 |
| Repeat treatment within 7 days of discharge‡, n (%) | 66 | 18 (27.3) | 71 | 15 (21.1) | 0.401 |
| Still taking antiemetics at 7 days postdischarge, n (%) | 59 | 57 (96.6) | 64 | 51 (79.7) | 0.004 |
*Comparisons between inpatient treatment and outpatient therapy were evaluated using χ2 test for categorical variables, t-test for scores/ratings, reduction in ketonuria and change in weight and Wilcoxon rank-sum test for duration of index presentation as distribution was positively skewed.
†Reattendance to emergency department within 7 days following discharge.
‡Repeat inpatient/outpatient treatment within 7 days following discharge.
PPT, patient preference trial; PUQE, Pregnancy Unique Quantification of Emesis; RCT, randomised control trial.