Fig 1. Study design for the SIV infection, antiretroviral treatment and IL-7 therapy administration of Rhesus macaques.

Animals were infected with SIV at day 0, and antiretroviral (ART) was initiated 105 days post-infection (d.p.i), with a dose reduction 128 d.p.i. Animals who were administered rsIL-7-gly received 3 clusters of rsIL-7gly administered s.c. weekly for 3 weeks followed by 2 weeks between each cluster. All animals were administered BrDu daily for 4 days, starting 149 d.p.i. Each vertical line corresponds to date on which a collected plasma sample was utilized for the quantification of sCD127 in this study.