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. 2017 Dec 19;12(12):e0188649. doi: 10.1371/journal.pone.0188649

Fig 7. Summary graphical diagram.

Fig 7

Intrahepatic ILC2 are characterized by expression of CD127 and CRTH2, which binds PDG2. They express tissue residence maker CD69; CD161; the IL-2 cytokine receptor CD25; liver and tissue homing chemokine receptors CXCR3 and CCR6 and cytokine receptor ST2, which bind respectively to IP-10, CCL20 and IL-33 produced by biliary epithelial cells upon stimulation with inflammatory cytokines or bacteria. ILC2 secrete IL-13 and amphiregulin, which may contribute to bile duct regeneration. In addition, they express the integrins VLA-5 and VLA-6, which attach to the extracellular matrix proteins fibronectin and laminin found in the fibrous stroma.