Author response image 1. Jak2 inhibition either by AG490 or knock down using shRNA (#61) similarly prevents the increase in transcriptional activity of an Atoh1-specific reporter in DAOY cells.

Combining the inhibitor with genetic knock down does not result in any further inhibition of Atoh1 activity, consistent with Jak2 being the major component responsible for the modulation of Atoh1 (n=36 in duplicates, One-way ANOVA compared to Y78, Dunnett's multiple comparisons test. ****p<0.0001, ns=not significant).