Table 5.
Association of baseline and rate of increase in eGFR (mL/min/1.73 m2) and UACR (mg/g) with posterior wall thickness (cm) and septal wall thickness (cm) (n = 539) from multiple regression analysis
| Variables | Posterior Wall Thickness (M Mode) |
Septal Wall Thickness (M Mode) |
||
|---|---|---|---|---|
| β Coefficient (95% CI) | P Value | β Coefficient (95% CI) | P Value | |
| Baseline eGFR | 0.0001 (−0.0007, 0.0008) | .83 | 0.0003 (−0.0005, 0.0012) | .44 |
| Baseline UACR | 0.0114 (0.0025, 0.0203) | .013 | 0.0120 (0.0021, 0.0219) | .018 |
| Rate of decline in eGFR∗ | −0.0075 (−0.0132, −0.0019) | .009 | −0.0010 (−0.0072, 0.0053) | .76 |
| Rate of increase in UACR† | .048 | .019 | ||
| <0.14 (Ref) | ||||
| 0.14–1.07 | 0.0260 (0.0028, 0.0492) | .028 | 0.0285 (0.0028, 0.0542) | .03 |
| ≥1.07 | 0.0232 (0.0011,0.0452) | .039 | 0.0329 (0.0085, 0.0573) | .008 |
| Gender (female) | −0.0320 (−0.0548, −0.0092) | .006 | −0.0362 (−0.0614, −0.0109) | .005 |
| Waist circumference | 0.0024 (0.0015, 0.0032) | <.001 | 0.0022 (0.0013, 0.0032) | <.001 |
| Baseline SBP | 0.0014 (0.0006, 0.0021) | <.001 | 0.0015 (0.0007, 0.0023) | <.001 |
| SBP change‡ | 0.0007 (0.0001, 0.0013) | .022 | 0.0006 (−0.0001, 0.0013) | .098 |
ARB, angiotensin II receptor blocker; ACEI, angiotensin-converting enzyme inhibitor; CCB, calcium channel blocker; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoprotein; SBP, systolic blood pressure; UACR, urine albumin-to-creatinine ratio.
Note: Variables in the model were baseline eGFR, baseline UACR, rate of decline in eGFR, rate of increase in UACR, age, gender, education, waist circumference, diabetes, heart disease, SBP, SBP change, DBP, DBP change, smoking, LDL, HDL, triglyceride, ACEI or ARB use, CCB use, β-blocker use, diuretics use, and intervention group.
All models accounted for clustering effect by household as a random effect.
In addition to kidney function biomarkers, variables with P value < .05 for either outcomes were reported in the table.
Rate of decline in eGFR = (eGFR at year 7 − eGFR at baseline)/duration of follow-up (in y).
Rate of increase in UACR = (UACR at year 7 − UACR at baseline)/duration of follow-up (in y).
Change in SBP was calculated using SBP at year 7 minus baseline SBP.