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. Author manuscript; available in PMC: 2017 Dec 19.
Published in final edited form as: Biomacromolecules. 2017 Oct 11;18(11):3753–3765. doi: 10.1021/acs.biomac.7b01349

Figure 1.

Figure 1

NP facilitate significant and differential siRNA uptake across multiple cell types and species. Murine tenocytes (A), murine MSCs (mMSC) (B), and human MSCs (hMSC) (C) were treated with 30 nM fluorescent siRNA complexed to NP at a charge ratio of 4:1. Median fluorescence intensity (MFI) was detected via flow cytometry and normalized to negative controls within each cell type. *p < 0.05 compared to negative control (–), #p < 0.01 compared to positive (+) control. Negative controls (–) are comprised of untreated cells and positive controls (+) are cells treated with 30 nM siRNA using Lipofectamine2000.