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. Author manuscript; available in PMC: 2017 Dec 19.
Published in final edited form as: Biomacromolecules. 2017 Oct 11;18(11):3753–3765. doi: 10.1021/acs.biomac.7b01349

Scheme 1. Diblock Copolymers Form Cationic Nanoparticles (NP) via Self-Assembly That Can Complex with Negatively Charged siRNAa.

Scheme 1

a(A) Diblock copolymer structure showing cationic first block composed of dimethylaminoethyl methacrylate (DMAEMA), and a pH-responsive hydrophobic tercopolymer second block composed of DMAEMA, propylacrylic acid (PAA), and butyl methacrylate (BMA) that drives self-assembly and allows endosomal escape. R and Z are functional end groups. (B) Self-assembled cationic NP electrostatically complex with negatively charged siRNA.