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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: J Immunol. 2017 Nov 29;200(1):316–326. doi: 10.4049/jimmunol.1602017

Figure 1. Mouse FH and FHR gene family and schematic representation of recombinant mFH and mFHR proteins.

Figure 1

A) Representation of mFH and mFHR genes and their locations on mouse chromosome 1. Boxed regions indicate genes listed by some databases as unprocessed pseudogenes. B) Similar to human FH, mFH has 20 SCR domains. The first four domains are involved in regulation and C3b binding. The next four domains are involved in glycosaminoglycan (GAGs) binding and the last two domains are involved in C3b/C3d and GAG binding. Two of the mouse FHR proteins, mFHR-B and mFHR-C, have been previously described. The mFHR-A prototype is designed based on a sequence described by Vik et al. 1990. The mFHR proteins A–C are shown with their SCR domains (numbered inside each circle) aligned with SCR domains of mFH (with percentage homology with mFH shown below each SCR).