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Pre-clinical in vivo PK for compound 27 after 25 mg/kg oral dose was administered to a rat.
| Cmax (ng/mL) | tmax (h) | AUClast ((h)*(ng/mL)) | thalf (h) | %F | |
|---|---|---|---|---|---|
|
|
|||||
| 27 | 6222.1 | 1.7 | 83173.60 | 2.04 | 42.5 |
| 1aa | ND | ND | ND | ND | 0% |
Plasma concentrations of 1a were under the lowest detectable limit, so all PK parameters after 25 mg/kg oral dose could not be calculated
