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. Author manuscript; available in PMC: 2018 Dec 18.
Published in final edited form as: Dev Cell. 2017 Nov 2;43(6):673–688.e5. doi: 10.1016/j.devcel.2017.10.011

Figure 5. p-4EBP1 levels in human medulloblastoma.

Figure 5

(A) Immunostaining for p-4EBP1 showed high- (top panels) or intermediate-level staining (bottom-left panel) in human SHH-group medulloblastoma, whereas only focal, low-level staining was observed in non-SHH/non-WNT medulloblastoma (bottom-right panel). (B) Mosaic plot for 90 medulloblastomas displaying the proportion of p-4EBP1 staining levels in each subgroup. The p-4EBP1 staining was significantly enriched in the SHH group, as compared with that in the non-SHH/non-WNT group (P = 0.0005 by the chi-square test), and the staining level in the SHH-group was greater than that in the non-SHH/non-WNT group (P = 0.0005 by the chi-square test). (C) Immunostaining for p-4EBP1 in mice. p-4EBP1 levels were high in WNT tumors with a Pik3ca mutation but undetectable in WNT tumors without a Pik3ca mutation and in group 3 tumors. Scale bar = 200 μm (A), 50 μm (B).