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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Eur J Med Chem. 2017 Nov 4;143:1919–1930. doi: 10.1016/j.ejmech.2017.11.006

Table 4.

In vitro anti-proliferative activities of selected potent thio-barbituric acid derivatives (from Table 1) on pancreatic, breast, and colon cancer cells (48 h treatment).a

Compounds Cancer cells (IC50, μM)
Pancreatic cancer Breast Cancer Colon cancer
Panc-1 MDA-MB-231 MCF-7 HCT-116
2a 24.4 ± 3.7 16.5 ± 1.8 27.9 ± 4.2 20.1 ± 3.5
2b 19.1 ± 2.9   7.6 ± 2.1 16.2 ± 3.2   7.7 ± 0.6
2d   7.9 ± 1.7   4.5 ± 0.9   4.4 ± 1.1   3.6 ± 1.4
8b   8.3 ± 3.1   8.3 ± 2.7 16.5 ± 1.7   2.4 ± 0.9
8c 21.0 ± 3.9   8.6 ± 1.3 23.5 ± 2.3 18.2 ± 1.8
8e 20.5 ± 2.5   8.5 ± 2.9 24.0 ± 0.5   8.3 ± 3.2
a

Values are the mean of triplicates of at least two independent experiments. Non-linear graphs using Prism software were used to determine Mean ± SD values.