TABLE I.
Baseline patient characteristics
| Characteristic | Cohort | |
|---|---|---|
|
| ||
| 2003–2006 | 2010–2011 | |
| Patients (n) | 922 | 560 |
| Sex [n (%)] | ||
| Men | 475 (52) | 292 (52) |
| Women | 447 (48) | 268 (48) |
| Median age (years) | ||
| Median | 69 | 70 |
| Range | 32–96 | 20–97 |
| Smoking status [n (%)] | ||
| Current smoker | 297 (32) | 162 (29) |
| Former smoker | 492 (53) | 263 (47) |
| Nonsmoker | 92 (10) | 55 (10) |
| Unknown | 41 (5) | 80 (14) |
| Pulmonary embolism [n (%)] | 385 (42) | 209 (37) |
| ECOG functional status [n (%)] | ||
| 0 | 48 (5) | 33 (6) |
| 1 | 147 (16) | 88 (16) |
| 2 | 120 (13) | 52 (9) |
| 3 | 99 (11) | 38 (7) |
| 4 | 18 (2) | 6 (1) |
| Unknown | 490 (53) | 343 (61) |
| Other malignancies present [n (%)] | 154 (17) | 93 (17) |
| Tumour histology [n (%)] | ||
| Adenocarcinoma | 398 (43) | 294 (53) |
| Adenosquamous: 6 (<1) | 4 (<1) | |
| Adenocarcinoma in situ or bronchioalveolar carcinoma | 8 (1) | 3 (<1) |
| Squamous cell carcinoma | 169 (18) | 94 (17) |
| Large cell | 25 (3) | 11 (2) |
| Not otherwise specified | 316 (34) | 140 (25) |
| Unknown | 0 (0) | 14 (3) |
| EGFR receptor status [n (%)] | ||
| Not done | 920 (100) | 230 (41) |
| Positive | 114 (20) | |
| Negative | 193 (34) | |
| Unknown | 23 (4) | |