Table 3.
Number of Low-Risk Lifestyle Factors and Risk of Incident Diverticulitis
| Number of Low-Risk Lifestyle Factors1 | Pearson-Years (%) | Cases, No. | Incidence per 100,000 Person-Years2 | Age-adjusted RR3 (95% CI) | p for trend4 | Multivariable RR5 (95% CI) | p for trend4 |
|---|---|---|---|---|---|---|---|
| 0 | 91,410 (12%) | 172 | 183 | 1.00 [Reference] | <0.001 | 1.00 [Reference] | <0.001 |
| 1 | 201,485 (27%) | 269 | 131 | 0.70 (0.58, 0.85) | 0.71 (0.59, 0.87) | ||
| 2 | 205,159 (27%) | 247 | 119 | 0.66 (0.54, 0.80) | 0.66 (0.55, 0.81) | ||
| 3 | 150,828 (20%) | 138 | 91 | 0.49 (0.39, 0.61) | 0.50 (0.40, 0.62) | ||
| 4 | 83,264 (11%) | 69 | 82 | 0.45 (0.34, 0.60) | 0.47 (0.35, 0.62) | ||
| 5 | 25,645 (3%) | 12 | 49 | 0.26 (0.14, 0.46) | 0.27 (0.15, 0.48) |
CI, confidence interval; NSAID, non-steroid anti-inflammatory drug; RR, relative risks.
1
Low risk factors: red meat intake < 51 grams daily, dietary fiber intake in highest 40% of the cohort, vigorous physical activity in the top 2 quartiles after excluding participants with no vigorous physical activity, normal body weight, and never smoker.
2
Incidence is directly standardized to age distribution (in 5-year age group) of all the participants.
3
Adjusted for age and questionnaire cycle.
4
Calculated using continuous variables.
5
Additionally adjusted for and total energy intake (quintiles), regular use of aspirin, NSAID, and acetaminophen.